Obama's three-day journey to the region also means visits to Thailand and Cambodia, where he will attend the East Asia Summit.
In Myanmar, also known as Burma, Obama will "speak to civil society to encourage Burma's ongoing democratic transition," according to the White House. He will meet with President Thein Sein and activist Aung San Suu Kyi.
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The trip comes as Myanmar's new reformist president has created a opening for further democracy there.
Under Thein Sein, the Myanmar government has released hundreds of political prisoners in the past year, part of a series of reforms that have followed decades of repressive military rule. Western governments have responded to the efforts by starting to ease sanctions put in place to pressure the military regime.
Myanmar authorities have also engaged in peace talks with rebel ethnic groups and allowed Suu Kyi's party, the National League for Democracy, to successfully participate in special elections for the national parliament in April.
"I think the president's message when he goes is going to be one of welcoming the progress that has taken place, noting the truly historic developments that we've seen over the course of the last year, but also underscoring that more work needs to be done to insure a full transition to civilian rule to ensure a full transition to democracy, and to bring about national reconciliation," said Ben Rhodes, deputy national security adviser for strategic communications.